Clare Zhang Curriculum Vitae
Y. CLARE ZHANG, PhD, MAcOM, LAc 
Practice of Oriental Medicine 
Tucson, Arizona 

Educational Background 
• Bachelor of Engineering, Biochemical Engineering, Shanghai Jiaotong 
University, Shanghai, China, 1992 
• Doctor of Philosophy, Physiology, University of Florida, Gainesville, FL, 2000 
• Master in Acupuncture & Oriental Medicine, Arizona School of Acupuncture & 
Oriental Medicine, Tucson, AZ, 2010 
• Internship, Nephrology and Gastroenterology of Chinese Medicine, Hubei 
Chinese Medicine Hospital, Wuhan, China, Sept-Dec 2010 

Licenses and Credentials 
• Diplomate in Oriental Medicine, National Commission for the Certification of 
Acupuncture & Oriental Medicine, 2010 
• Licensed Acupuncturist, State of Arizona, 2010 

Professional Experience 
• Research Associate, Shanghai Institute of Biochemistry, Chinese Academy of 
Sciences, Shanghai, China, 1992-1996 
• Research Assistant, Department of Physiology, University of Florida, Gainesville, 
FL, 1996-2000 
• Post-doctoral Research Fellow, Department of Pathology, University of Florida, 
Gainesville, FL, 2000-2003 
• Assistant Professor, Department of Pediatrics, University of South Florida, 
Tampa, FL, 2003-2008 
• Visiting Scholar, Department of Cell Biology & Anatomy, University of Arizona, 
Tucson, AZ, 2007-2008 
• Practitioner of Acupuncture & Oriental Medicine, Tucson, AZ, 2010-present 

Honors and Awards 
• International Student Fellowship, Council for International Cooperation, 1996 
• Exceptional Honors-GPA 4.0, University of Florida, 1996 
• First Place Winner of Medical Guild Graduate Student Research Award; 
International Graduate Student Academic Achievement Award, University of 
Florida, 1999 
• Hypertension Summer School Travel Award, American Heart Association, 1999 
• American Heart Association Predoctoral Fellowship, 1998-2000 
• Young Investigators-in-Training Award, American Society of Hypertension, 2000 
• Professional Opportunity Award, American Physiology Society, 2000 
• Travel Fellowship Grant, Society for Experimental Biology and Medicine, 2000 
• Research Grant, National Institute of Health, 2001 
• Innovative Research Award, Juvenile Diabetes Research Foundation, 2003 
• Scientist Development Award, American Heart Association, 2004 

• Research Rising Stars Award, University of South Florida, 2005 
• Valedictorian, Arizona School of Acupuncture & Oriental Medicine, 2010 

Patents 
• U.S. Patent No. 6,087,343, “Antisense oligonucleotides targeted to β1- 
adrenoceptor and methods of use”, 2000 
• U.S. Patent No. 6,489,307, “Antisense compositions targeted to β1-adrenoceptorspecific 
mRNA and methods of use”, 2002 

Scientific Services 
• Associate Editor, Regulatory Peptides, 2003-2006 
• Invited reviewer for scientific journals Gene Therapy, Transplantation, 
Diabetes/Metabolism Research and Reviews 

Societies and Memberships 
• American Heart Association 
• American Physiology Society 
• Society for Experimental Biology and Medicine 
• American Society of Hypertension 
• American Diabetes Association 
• American Association of Acupuncture and Oriental Medicine 
• Arizona Society of Oriental Medicine and Acupuncture 

Publications 
1. YC Zhang, YD Zhang, C Chang, YL Zhang. Differential regulation of glutathione Stransferase 
Yb1 mRNA levels in rat prostate, liver and brain by androgen. Cell 
Research, 1995, 5:235-242. 
2. YC Zhang, et al. Studies of the expression of estrogen receptor gene in the rat uterus 
during the estrous cycle and periimplantational period. Reproduction & 
Contraception, 1995, 6: 65-73. 
3. YC Zhang, GZ Zhu, YD Zhang, YL Zhang. Studies of the expression of 
progesterone receptor gene in the rat uterus during early pregnancy by RT-PCR. Acta 
Biochimica et Biophysica Sinica, 1997, 29(3): 221-228. 
4. BC Yang, MI Phillips, YC Zhang, B Kimura, LP Shen, P Mehta, JL Mehta. Critical 
role of AT1 receptor expression after ischemia/reperfusion in isolated rat hearts. 
Circulation Research, 1998, 83(5): 552-559. 
5. DY Li, YC Zhang, BC Yang, MI Phillips, JL Mehta. Upregulation of endothelial 
receptor for ox-LDL in cultured human coronary artery endothelial cells by 
angiotensin II type 1 receptor activation. Circulation Research, 1999, 84: 1043-49. 
6. XP Tang, D Mohuczy, YC Zhang, B Kimura, SM Galli, MI Phillips. Systemic 
delivery of antisense against angiotensinogen mRNA by adeno-associated virus-based 
plasmid vector decreases hypertension. American Journal of Physiology, 1999, 277 
(Heart Circ. Physiol. 46): H2392-H2399. 
7. YC Zhang, JD Bui, L Shen, MI Phillips. Antisense inhibition of β1-adrenocepotor 
mRNA in a single dose produces a profound and prolonged reduction in high blood 

pressure in spontaneously hypertensive rats. Circulation, 2000, 101: 682-688. 
(Selected in 2001 Year Book of Cardiology) 
8. YC Zhang, B Kimura, L Shen, MI Phillips. New β-blocker: prolonged reduction in 
high blood pressure with β1 antisense oligodeoxynucleotides. Hypertension, 2000, 
35(part 2): 219-224. 
9. HJ Chen, YC Zhang, DY Li, MI Phillips, P Mehta, M Shi, JL Mehta. Protection 
against myocardial ischemia-reperfusion-induced cardiac dysfunction by antisenseoligodeoxynucleotides 
directed at β1-adrenoceptor mRNA. J. Pharmacol. Exp. Ther., 
2000, 294(2):722-727. 
10. MI Phillips, YC Zhang. Basic principles of using antisense oligonucleotides in vivo. 
Methods in Enzymology, 2000, vol. 313, Antisense Technology Part A, p46-56, 
Academic Press. 
11. K Goudy, S Song, C Wasserfall, YC Zhang, M Kapturczak, A Muir, M Powers, M 
Scott-Jorgensen, M Campbell-Thompson, JM Crawford, TM Ellis, TR Flotte, MA 
Atkinson. Adeno-associated virus vector-mediated IL-10 gene delivery prevents type 
1 diabetes in NOD mice. Proc Natl Acad Sci U S A, 2001, 98: 13913-8. 
12. YC Zhang, RD Molano, A Pileggi, M Powers, J Cross, C Wasserfall, M Jorgensen, 
M Campbell-Thompson, JM Crawford, T Flotte, TM Ellis, C Ricordi, MA Atkinson, 
L Inverardi. Interleukin-4 expressed from adeno-associated virus transduced islet 
grafts fails to enhance the reversal towards normoglycemia in a syngeneic marginal 
mass islet transplantation model. Transplantation, 2002, 74:1184-1186. 
13. S Kagiyama, S Eguchi, GD Frank, T Inagami, YC Zhang, MI Phillips. Angiotensin 
II-induced cardiac hypertrophy and hypertension are attenuated by epidermal growth 
factor receptor antisense. Circulation, 2002, 106: 909-12. 
14. YC Zhang, A Pileggi, RD Molano, M Powers, C Wasserfall, T Brusko, T Flotte, TM 
Ellis, C Ricordi, MA Atkinson, L Inverardi. Adeno-associated virus mediated 
interleukin-10 gene therapy inhibits autoimmune diabetes recurrence in syngeneic 
islet cell transplantation of NOD mice. Diabetes, 2003, 52:708-16. 
15. YC Zhang, M Powers, C Wasserfall, T Brusko, T Flotte, R Snyder, M Potter, M 
Jorgensen, M Campbell-Thompson, JM Crawford, TM Ellis, MA Atkinson. Immune 
responsiveness imparted by genetic predisposition to autoimmunity to AAV-delivered 
transgenes. Gene Therapy, 2004, 11:233-40. (Accompanied by an editorial, Gene 
Therapy, 2004, 11:231-232) 
16. YL Tang, Y Tang, YC Zhang, K Qian, L Shen, MI Phillips. Preventing ischemic 
heart injury by vigilant plasmid mediated heme oxygenase-1 gene transfer. 
Hypertension. 2004, 43:746-51. (Accompanied by an editorial, Hypertension, 2004, 
43:720-21). 
17. YL Tang, Q Zhao, YC Zhang, MI Phillips, et al, Autologous mesenchymal stem cell 
transplantation induces VEGF and neovascularization in ischemic myocardium. 
Regulatory Peptides, 2004, 117:3-10. 
18. YC Zhang, MA Atkinson. Gene therapy for type 1 diabetes: metabolism, immunity, 
islet cell preservation and regeneration. Current Opinion in Endocrinology & 
Diabetes, 2004, 11(2): 91-97. 
19. YC Zhang, A Pileggi, RD Molano, C Wasserfall, M Campbell-Thompson, C Ricordi, 
MA Atkinson, L Inverardi. Systemic overexpression of interleukin-10 fails to protect 

allogeneic islet transplants in Non-obese diabetic mice. Transplantation, 2005, 
80:530-33. 
20. YC Zhang, M Powers, MA Atkinson, T Flotte. Measurement of humoral and cellmediated 
immune responses to AAV vector administration. Methods in Molecular 
Medicine, in press. 
21. BR Burkhardt, MJ Parker, YC Zhang, S Song, CH Wasserfall, MA Atkinson. 
Glucose Transporter-2 (GLUT2) Promoter Mediated Transgenic Insulin Production 
Reduces Hyperglycemia in Diabetic Mice. FEBS Letter, 2005, 579:5759-64. 
22. YC Tang, Y Tang, YC Zhang, K Qian, L Shen, MI Phillips. Improved graft 
mesenchymal stem cell survival in ischemic heart with a hypoxia-regulated Heme 
Oxygenase-1 Vector. Journal of the American College of Cardiology, 2005, 46:1339- 
50. (Accompanied by an editorial, JACC, 46: 1351-53). 
23. YL Tang, K Qian, YC Zhang, L Shen, MI Phillips. Mobilizing of haematopoietic 
stem cells to ischemic myocardium by plasmid mediated stromal-cell-derived factor- 
1α (SDF-1α) treatment. Regulatory Peptides, 2005, 125:1-8. 
24. YL Tang, Y Tang, YC Zhang, A Agarwal, H Kasahara, K Qian, L Shen, MI Phillips. 
A hypoxia-inducible vigilant vector system for activating therapeutic genes in 
ischemia. Gene Therapy, 2005, 12:1163-70. 
25. YL Tang, K Qian, YC Zhang, L Shen, MI Phillips. A vigilant hypoxia-regulated 
heme oxygenase-1 gene vector in the heart limits cardiac injury after ischemiareperfusion 
in vivo. J Cardiovas Pharmacol Therapeut, 2005, 10: 251-63. 
26. YC Zhang, MM Taylor, WK Samson, S Kagiyama, MI Phillips. Antisense inhibition: 
oligonucleotides, ribozymes and siRNAs. Methods in Molecular Medicine, 2005, 106: 
11-34. 
27. BR Burkhardt, R Lyle, K Qian, AS Arnold, H Cheng, MA Atkinson, YC Zhang. 
Efficient Delivery of siRNA into Cytokine-stimulated Insulinoma Cells Silences Fas 
Expression and Inhibits Fas-mediated Apoptosis. FEBS Letters, 2006, 580:553-560. 
28. AS Arnold, YL Tang, K Qian, L Shen, V Valencia, MI Phillips, YC Zhang. Specific 
β1-adrenergic receptor silencing with siRNA lowers high blood pressure and 
improves cardiac function in myocardial ischemia. Journal of Hypertension, 2007, 
25:197-205. 
29. MI Phillips, YC Zhang. Gene therapy for hypertension: a promise waiting to be 
fulfilled. Genetics of Hypertension, 2007, volume 24, chapter 14, p239-251, Elsevier. 
30. H Cheng, S Wolfe, V Valencia, K Qian, L Shen, MI Phillips, LJ Chang, YC Zhang. 
Efficient and persistent transduction of exocrine and endocrine pancreas by adenoassociated 
virus type 8. Journal of Biomedical Science, 2007, 14􀄟585-594. 
31. C Shen, Q Li, YC Zhang, G Ma, Y Feng, Q Zhu, Q Dai, Z Chen, Y Yao, L Chen, Y 
Jiang, N Liu. Advanced glycation end products increase EPC apoptosis and decrease 
nitric oxide release via MAPK pathways. Biomedicine & Pharmacotherapy, 2010, 
64(1):35-43.